10 Health and Performance Benefits of Creatine Creatine is a natural supplement often used to improve athletic performance. It may also boost brain function, fight certain neurological diseases, and accelerate muscle growth. 1. Helps muscle cells produce more energy. 2. Supports many other functions in muscles 3. Improves high-intensity exercise performance 4. Speeds muscle growth 5. May help with Parkinson’s disease 6. May fight other neurological diseases 7. May lower blood sugar levels and fight diabetes 8. Can improve brain function 9. May reduce fatigue and tiredness 10. Safe and easy to use